This publication presents ten scalable intercultural collaboration experiences that demonstrate the importance, efficiency and effectiveness of working hand in hand with men, women and youth of indigenous and Afro-descendant peoples of Latin America and the Caribbean in the search for practical solutions developed from the synergy between ancestral knowledge and scientific and technological innovation. Indigenous peoples and Afro-descendants are two of the rural groups with the greatest potential to contribute to climate change mitigation in Latin America. Both groups are highly vulnerable to natural disasters and the effects of climate on agriculture and food, yet their ancestral knowledge and collective territorial practices make them key allies in climate change mitigation.