This publication analyses the synergies and trade-offs that can occur within climate-smart agriculture (CSA), more specifically between its three pillars: (i) sustainably increasing productivity and incomes in agriculture, (ii) building resilience of and adapting food and agriculture systems to climate change, (iii) reducing/removing greenhouse gas emissions, where possible. The aim of this analysis is to develop a systematic characterization of possible synergies and trade-offs in CSA, as well as provide a tool to guide CSA practitioners through the assessment of synergies and trade-offs during the design and planning of CSA strategies or interventions. The ultimate objective is to support strategic decisions that enhance synergies and reduce trade-offs to achieve better results for investments in CSA.