Climate change can increase gender inequalities: while men can diversify into other commodities or migrate to other regions in search of economic opportunities in response to climate impacts, women often have more limited options, and therefore less resilience, due to their domestic responsibilities and poor access to resources and services. Failure to recognize the multiple roles performed by women along the agrifood value chain, and to address their specific needs and priorities often reduces their economic and social opportunities. This brief showcases promising research and innovation, particularly from countries engaged through the Food and Agriculture Organization of the United Nations (FAO) Flexible Multi-Partner Mechanism (FMM) 149 project. Senegal, Samoa and Zambia are highlighted as examples to inform policymakers, guide gender-responsive investments, policies, and strategies in countries’ work in response to climate change.