Amid accelerating biodiversity loss and growing threats to ecosystems, sustainable agrifood systems can play a crucial role in reversing these trends while ensuring food security for a growing global population. Agrifood systems are directly linked to more than half of the 23 targets of the Kunming-Montreal Global Biodiversity Framework and, in some way, to all the others. Therefore, agrifood sectors have a significant role in the planning, implementation, and monitoring of actions necessary to meet the framework's targets. By highlighting the connections between the KMGBF and agrifood sectors, this publication aims to facilitate the engagement of agrifood stakeholders in the framework's implementation.