This paper presents a new methodological approach aimed at measuring progress towards sustainable agriculture in countries and across agri-food systems typologies, by measuring socio-economic and environmental dimensions with available national statistics, with sixteen indicators defined and constructed from FAOSTAT data. A trend analysis is carried out at country level over the time series 1961–2018, with country results aggregated by four agri-food systems typologies: traditional; land-intensive and capital-intensive mixed systems; and modern food systems. The analysis provides a novel framework for the analysis of progress in achieving sustainable agriculture by country and agri-food system type, that can be implemented effectively and allows for exploring solutions across development pathways.