This paper is part of a series detailing new methodologies for estimating key components of agrifood systems emissions, with a view to disseminate the information in FAOSTAT. It describes methods for estimating greenhouse gas (GHG) emissions from the agrifood system, and in particular fluorinated gases (F-gases) from refrigeration systems in the food system cold chain, from food processing to food transport, retailing and household consumption processes. Based on the proposed methodology, we build a new database of GHG from F-gases used in the agrifood system, by country and with global coverage, for the period 1990–2021.